Infective endocarditis (IE) is an infection of the heart; to be more precise, of the endocardium of the heart, leading to valvular damage, heart failure and death if untreated. Bacterial infection is the most common cause and there is often a predisposing condition (most important being previous valve damage) that results in an altered blood flow. Intravenous drug abuse, prosthetic heart valves and other intravascular procedures are important risk factors.
IE can manifest as an acute or sub-acute presentation with fever, changing heart murmur and symptoms and signs of septic emboli and immunological phenomenon, etc. Diagnosis often requires blood cultures and echocardiography. Duke criteria (2 major and 6 minor criteria) are used to establish a diagnosis. Treatment involves the use of high dose IV antibiotics to eradicate the infection and addressing the complications. Surgical treatment is required in many patients.
Ontological engineering approach
I plan to develop this OWL model using BFO framework [http://www.ifomis.org/bfo] and the OBO Foundry principles [http://www.obofoundry.org/crit.shtml]. It will extend the Infectious Disease Ontology (IDO) which in turn imports OGMS and BFO. The naming conventions to be followed use the OBO Foundry recommendations [http://www.obofoundry.org/wiki/index.php/Naming] and [http://www.obofoundry.org/wiki/index.php/NewConventions].
I will be using a bunch of freely available tools including google docs and Protege editor to develop the OWL model.
– Google Spreadsheet for list of Terms, definitions etc – this will be updated over time.
– Protege 4.1 for ontology model development.